Big chain drugstores like CVS and Rite Aid make most of their profits on prescriptions. On the other hand, wholesalers like Costco and Sam's Club use the pharmacy as a way to get people into the store. Note that you don't have to be a Costco member to use a Costco pharmacy. Independent pharmacies are in between.
A few years ago, the price on pills at Rite Aid and Long's was 500-600% above MSRP (manufacturer's suggested retail price), whereas it was cost + 2-3% at WalMart. At this point, the price difference can amount to about $780 a year for the average patient.
h/t AlterNet, Consumer Reports
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